Polygenic Risk Score Identifies Subgroup with Higher Burden of...
Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth AS, Rader DJ, Ford I, Sattar N, Kathiresan S.
View ArticleIs Coronary Atherosclerosis One Disease or Many? Circulation....
Khera AV, Kathiresan S.
View ArticleANGPTL3 Deficiency and Protection Against Coronary Artery Disease. JACC....
Nathan O. Stitziel, MD, PHD, Amit V. Khera, MD, Xiao Wang, PHD, Andrew J. Bierhals, MD, MPH, A. Christina Vourakis, BA, Alexandra E. Sperry, BA, Pradeep Natarajan, MD, Derek Klarin, MD, Connor A....
View ArticleHuman knockouts and phenotypic analysis in a cohort with a high rate of...
Danish Saleheen, Pradeep Natarajan, Irina M. Armean, Wei Zhao, Asif Rasheed, Sumeet A. Khetarpal, Hong-Hee Won, Konrad J. Karczewski. Anne H. O’Donnell-Luria, Kaitlin E. Samocha, Benjamin Weisburd,...
View ArticleCardiovascular endocrinology: Is ANGPTL3 the next PCSK9? Nature Reviews...
Is ANGPTL3 the next PCSK9? Recent reports suggest that molecular therapies targeting ANGPTL3 and its encoded protein angiopoietin-like protein 3 have clinical potential comparable to therapies...
View ArticleA Genetic Variant Associated with Five Vascular Diseases Is a Distal...
Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection,...
View ArticleGenome-wide polygenic scores for common diseases identify individuals with...
A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one...
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